Details

Autor(en) / Beteiligte

• Ferreira, Meghaan M.
• Ramani, Vishnu C.
• Jeffrey, Stefanie S.

Titel

Circulating tumor cell technologies

Ist Teil von

• Molecular oncology, 2016-03, Vol.10 (3), p.374-394

Ort / Verlag

United States: Elsevier B.V

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Wiley Online Library Journals

Beschreibungen/Notizen

• Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of CTCs lies in the ability to detect and isolate these rare cells using methods amenable to downstream characterization and other applications. In this review, we will provide an overview of current technologies used to detect and capture CTCs with brief insights into the workings of individual technologies. We focus on the strategies employed by different platforms and discuss the advantages of each. As our understanding of CTC biology matures, CTC technologies will need to evolve, and we discuss some of the present challenges facing the field in light of recent data encompassing epithelial-to-mesenchymal transition, tumor-initiating cells, and CTC clusters. •We present a comprehensive overview of CTC detection and capture technologies.•We provide a conceptual description of strategies used in different technologies.•We highlight the key features of individual technologies.•We discuss CTC technology performance in the context of clinical studies.