Details

Autor(en) / Beteiligte

• Fernández-Cadenas, Israel
• Mendióroz, Maite
• Giralt, Dolors
• Nafria, Cristina
• Garcia, Elena
• Carrera, Caty
• Gallego-Fabrega, Cristina
• Domingues-Montanari, Sophie
• Delgado, Pilar
• Ribó, Marc
• Castellanos, Mar
• Martínez, Sergi
• Freijo, Marimar
• Jiménez-Conde, Jordi
• Rubiera, Marta
• Alvarez-Sabín, José
• Molina, Carlos A
• Font, Maria Angels
• Grau Olivares, Marta
• Palomeras, Ernest
• Perez de la Ossa, Natalia
• Martinez-Zabaleta, Maite
• Masjuan, Jaime
• Moniche, Francisco
• Canovas, David
• Piñana, Carlos
• Purroy, Francisco
• Cocho, Dolores
• Navas, Inma
• Tejero, Carlos
• Aymerich, Nuria
• Cullell, Natalia
• Muiño, Elena
• Serena, Joaquín
• Rubio, Francisco
• Davalos, Antoni
• Roquer, Jaume
• Arenillas, Juan Francisco
• Martí-Fábregas, Joan
• Keene, Keith
• Chen, Wei-Min
• Worrall, Bradford
• Sale, Michele
• Arboix, Adrià
• Krupinski, Jerzy
• Montaner, Joan

Titel

GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke

Ist Teil von

• Stroke (1970), 2017-05, Vol.48 (5), p.1147-1153

Ort / Verlag

United States: American Heart Association, Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• BACKGROUND AND PURPOSE—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. METHODS—We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients. The discovery cohort was prospectively recruited and included 1494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score [Genotyping Reurrence Risk of Stroke]) and generated risk groups using a classification tree method. RESULTS—The analyses revealed that rs1800801 in the MGP gene (hazard ratio, 1.33; P=9×10), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305); however, it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (P=3.2×10) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared with previous Stroke Prognosis Instrument-II score (P=0.03). CONCLUSIONS—The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.