Details

Autor(en) / Beteiligte

• Byrareddy, Siddappa N.
• Arthos, James
• Cicala, Claudia
• Villinger, Francois
• Ortiz, Kristina T.
• Little, Dawn
• Sidell, Neil
• Kane, Maureen A.
• Yu, Jianshi
• Jones, Jace W.
• Santangelo, Philip J.
• Zurla, Chiara
• McKinnon, Lyle R.
• Arnold, Kelly B.
• Woody, Caroline E.
• Walter, Lutz
• Roos, Christian
• Noll, Angela
• Van Ryk, Donald
• Jelicic, Katija
• Cimbro, Raffaello
• Gumber, Sanjeev
• Reid, Michelle D.
• Adsay, Volkan
• Amancha, Praveen K.
• Mayne, Ann E.
• Parslow, Tristram G.
• Fauci, Anthony S.
• Ansari, Aftab A.

Titel

Sustained virologic control in SIV⁺ macaques after antiretroviral and α₄β₇ antibody therapy

Ist Teil von

• Science (American Association for the Advancement of Science), 2016-10, Vol.354 (6309), p.197-202

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2016

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the α₄β₇ integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4⁺ cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.