Details

Autor(en) / Beteiligte

• Schulze, P Christian
• Drosatos, Konstantinos
• Goldberg, Ira J

Titel

Lipid Use and Misuse by the Heart

Ist Teil von

• Circulation research, 2016-05, Vol.118 (11), p.1736-1751

Ort / Verlag

United States: American Heart Association, Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The heart utilizes large amounts of fatty acids as energy providing substrates. The physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids. Several processes that affect cardiac function, including ischemia, obesity, diabetes mellitus, sepsis, and most forms of heart failure lead to altered fatty acid oxidation and often also to the accumulation of lipids. There is now mounting evidence associating certain species of these lipids with cardiac lipotoxicity and subsequent myocardial dysfunction. Experimental and clinical data are discussed and paths to reduction of toxic lipids as a means to improve cardiac function are suggested.