Details

Autor(en) / Beteiligte

• Ibáñez-Sanz, Gemma
• Díez-Villanueva, Anna
• Alonso, M Henar
• Rodríguez-Moranta, Francisco
• Pérez-Gómez, Beatriz
• Bustamante, Mariona
• Martin, Vicente
• Llorca, Javier
• Amiano, Pilar
• Ardanaz, Eva
• Tardón, Adonina
• Jiménez-Moleón, Jose J
• Peiró, Rosana
• Alguacil, Juan
• Navarro, Carmen
• Guinó, Elisabet
• Binefa, Gemma
• Fernández-Navarro, Pablo
• Espinosa, Anna
• Dávila-Batista, Verónica
• Molina, Antonio José
• Palazuelos, Camilo
• Castaño-Vinyals, Gemma
• Aragonés, Nuria
• Kogevinas, Manolis
• Pollán, Marina
• Moreno, Victor

Titel

Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study

Ist Teil von

• Scientific reports, 2017-02, Vol.7 (1), p.43263-12, Article 43263

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2017

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5 quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1 quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.