Details

Autor(en) / Beteiligte

• Berger, Shelley L
• Sassone-Corsi, Paolo

Titel

Metabolic Signaling to Chromatin

Ist Teil von

• Cold Spring Harbor perspectives in biology, 2016-11, Vol.8 (11), p.a019463

Ort / Verlag

United States: Cold Spring Harbor Laboratory Press

Erscheinungsjahr

2016

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• There is a dynamic interplay between metabolic processes and gene regulation via the remodeling of chromatin. Most chromatin-modifying enzymes use cofactors, which are products of metabolic processes. This article explores the biosynthetic pathways of the cofactors nicotinamide adenine dinucleotide (NAD), acetyl coenzyme A (acetyl-CoA), S-adenosyl methionine (SAM), α-ketoglutarate, and flavin adenine dinucleotide (FAD), and their role in metabolically regulating chromatin processes. A more detailed look at the interaction between chromatin and the metabolic processes of circadian rhythms and aging is described as a paradigm for this emerging interdisciplinary field.