Nature medicine, 2016-10, Vol.22 (10), p.1090-1093
2016
Details
- Autor(en) / Beteiligte
- Titel
- Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[ 18 F]fluoro-D-glucose positron emission and computed tomography
- Ist Teil von
- Nature medicine, 2016-10, Vol.22 (10), p.1090-1093
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-8956eISSN: 1546-170XDOI: 10.1038/nm.4161Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5055809
- Format
- –
- Schlagworte
- Abnormalities, Adult, Adults, Analysis, Antiretroviral agents, Biomarkers, Care and treatment, CAT scans, Coinfection - diagnostic imaging, Computation, Computed tomography, CT imaging, Disease Progression, Female, Fluorodeoxyglucose F18, Glucose, Health aspects, HIV, HIV Infections - complications, HIV patients, Human immunodeficiency virus, Humans, Interferon-gamma Release Tests, Latent infection, Latent Tuberculosis - complications, Latent Tuberculosis - diagnostic imaging, Male, Mycobacterium tuberculosis - isolation & purification, Positron emission, Positron Emission Tomography Computed Tomography, Radiography, Thoracic, Radiopharmaceuticals, South Africa, Sputum - microbiology, Tuberculosis, Tuberculosis - complications, Tuberculosis - diagnostic imaging, Tuberculosis, Pulmonary - complications, Tuberculosis, Pulmonary - diagnostic imaging