Details

Autor(en) / Beteiligte

• Chapuis, Aude G
• Lee, Sylvia M
• Thompson, John A
• Roberts, Ilana M
• Margolin, Kim A
• Bhatia, Shailender
• Sloan, Heather L
• Lai, Ivy
• Wagener, Felecia
• Shibuya, Kendall
• Cao, Jianhong
• Wolchok, Jedd D
• Greenberg, Philip D
• Yee, Cassian

Titel

Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient

Ist Teil von

• The Journal of experimental medicine, 2016-06, Vol.213 (7), p.1133-1139

Ort / Verlag

United States: The Rockefeller University Press

Erscheinungsjahr

2016

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Adoptive transfer of peripheral blood-derived, melanoma-reactive CD8(+) cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky tumors. Similarly, monotherapy with anti-CTLA4 infrequently yields sustained remissions in patients with metastatic melanoma. We postulated that a bolus of enhanced IL-21-primed polyclonal antigen-specific CTL combined with CTLA4 blockade might boost antitumor efficacy. In this first-in-human case study, the combination successfully led to a durable complete remission (CR) in a patient whose disease was refractory to both monoclonal CTL and anti-CTLA4. Long-term persistence and sustained anti-tumor activity of transferred CTL, as well as responses to nontargeted antigens, confirmed mutually beneficial effects of the combined treatment. In this first-in-human study, Chapuis et al. demonstrate that the combination of adoptive cellular therapy with CTLA4 blockade induces long-term remission in a melanoma patient resistant to both modalities administered serially and individually.