Details

Autor(en) / Beteiligte

• Hobusch, Gerhard Martin
• Bodner, Florian
• Walzer, Sonja
• Marculescu, Rodrig
• Funovics, Philipp T
• Sulzbacher, Irene
• Windhager, Reinhard
• Panotopoulos, Joannis

Titel

C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum--a single center pilot study

Ist Teil von

• World journal of surgical oncology, 2016-04, Vol.14 (113), p.111-111, Article 111

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2016

Link zum Volltext

Quelle

2022 ECC(Springer)

Beschreibungen/Notizen

• This is a retrospective, diagnostic study, level IV. It appears to be necessary to identify prognostic markers for individual risk estimation for progression and survival in patients with chordoma, a rare disease. Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival? Survival rates of 24 patients (18 males, 6 females) (mean age 67 years (SD ± 16; range 20-85 years); minimum follow-up 2 years, mean follow-up 5 years (SD ± 5; range 2-19 years)) with chordoma of the lower spine and sacrum were assessed with a focus on pre-operative CRP levels. The survival rate of patients with pre-operative CRP level of >1.0 mg/dl was lower than that of patients with a CRP level <1.0 mg/dl (p = 0.01). The estimated 10-year survival of patients with pre-operative CRP values <1.0 and >1.0 mg/dl was 76 and 25%, respectively. CRP remained as an independent survival factor (p = 0.025; CI 95% 1.0-2.6) in multivariable analysis. Pre-operative CRP levels appear to be a biomarker for disease-specific survival in patients with chordoma of the lumbar spine and sacrum. A validation of our finding with larger cohorts and integration of putative risk factor would further elucidate CRP a surrogate for tumor progression.