Details

Autor(en) / Beteiligte

• Nellore, Anoma
• Fishman, Jay A

Titel

The Microbiome, Systemic Immune Function, and Allotransplantation

Ist Teil von

• Clinical microbiology reviews, 2016-01, Vol.29 (1), p.191-199

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Diverse effects of the microbiome on solid organ transplantation are beginning to be recognized. In allograft recipients, microbial networks are disrupted by immunosuppression, nosocomial and community-based infectious exposures, antimicrobial therapies, surgery, and immune processes. Shifting microbial patterns, including acute infectious exposures, have dynamic and reciprocal interactions with local and systemic immune systems. Both individual microbial species and microbial networks have central roles in the induction and control of innate and adaptive immune responses, in graft rejection, and in ischemia-reperfusion injury. Understanding the diverse interactions between the microbiome and the immune system of allograft recipients may facilitate clinical management in the future.