Details

Autor(en) / Beteiligte

• Bandopadhayay, Pratiti
• Ramkissoon, Lori A
• Jain, Payal
• Bergthold, Guillaume
• Wala, Jeremiah
• Zeid, Rhamy
• Schumacher, Steven E
• Urbanski, Laura
• O'Rourke, Ryan
• Gibson, William J
• Pelton, Kristine
• Ramkissoon, Shakti H
• Han, Harry J
• Zhu, Yuankun
• Choudhari, Namrata
• Silva, Amanda
• Boucher, Katie
• Henn, Rosemary E
• Kang, Yun Jee
• Knoff, David
• Paolella, Brenton R
• Gladden-Young, Adrianne
• Varlet, Pascale
• Pages, Melanie
• Horowitz, Peleg M
• Federation, Alexander
• Malkin, Hayley
• Tracy, Adam A
• Seepo, Sara
• Ducar, Matthew
• Van Hummelen, Paul
• Santi, Mariarita
• Buccoliero, Anna Maria
• Scagnet, Mirko
• Bowers, Daniel C
• Giannini, Caterina
• Puget, Stephanie
• Hawkins, Cynthia
• Tabori, Uri
• Klekner, Almos
• Bognar, Laszlo
• Burger, Peter C
• Eberhart, Charles
• Rodriguez, Fausto J
• Hill, D Ashley
• Mueller, Sabine
• Haas-Kogan, Daphne A
• Phillips, Joanna J
• Santagata, Sandro
• Stiles, Charles D
• Bradner, James E
• Jabado, Nada
• Goren, Alon
• Grill, Jacques
• Ligon, Azra H
• Goumnerova, Liliana
• Waanders, Angela J
• Storm, Phillip B
• Kieran, Mark W
• Ligon, Keith L
• Beroukhim, Rameen
• Resnick, Adam C

Titel

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Ist Teil von

• Nature genetics, 2016-03, Vol.48 (3), p.273-282

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2016

Link zum Volltext

Beschreibungen/Notizen

• Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in angiocentric gliomas. In vitro and in vivo functional studies show that MYB-QKI rearrangements promote tumorigenesis through three mechanisms: MYB activation by truncation, enhancer translocation driving aberrant MYB-QKI expression and hemizygous loss of the tumor suppressor QKI. To our knowledge, this represents the first example of a single driver rearrangement simultaneously transforming cells via three genetic and epigenetic mechanisms in a tumor.