Antimicrobial agents and chemotherapy, 2014-12, Vol.58 (12), p.7586-7591
2014
Details
- Autor(en) / Beteiligte
- Titel
- Antibacterial properties of magnesium in vitro and in an in vivo model of implant-associated methicillin-resistant Staphylococcus aureus infection
- Ist Teil von
- Antimicrobial agents and chemotherapy, 2014-12, Vol.58 (12), p.7586-7591
- Ort / Verlag
- United States: American Society for Microbiology
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Periprosthetic infection remains a challenging clinical complication. We investigated the antibacterial properties of pure (99.9%) magnesium (Mg) in vitro and in an in vivo rat model of implant-related infection. Mg was highly effective against methicillin-resistant Staphylococcus aureus-induced osteomyelitis and improved new peri-implant bone formation. Bacterial icaA and agr RNAIII transcription levels were also assessed to characterize the mechanism underlying the antibacterial properties of the Mg implant.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4804eISSN: 1098-6596DOI: 10.1128/AAC.03936-14Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4249557
- Format
- –
- Schlagworte
- Animals, Anti-Bacterial Agents, Anti-Bacterial Agents - pharmacology, Biofilms - drug effects, Biofilms - growth & development, Bone Density - drug effects, Bone Plates - microbiology, Bone Screws - microbiology, Disease Models, Animal, Experimental Therapeutics, Femur - drug effects, Femur - microbiology, Femur - surgery, Magnesium, Magnesium - pharmacology, Methicillin-Resistant Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus - drug effects, Methicillin-Resistant Staphylococcus aureus - growth & development, Microbial Sensitivity Tests, Osteomyelitis, Osteomyelitis - drug therapy, Osteomyelitis - microbiology, Osteomyelitis - surgery, Prosthesis-Related Infections, Prosthesis-Related Infections - drug therapy, Prosthesis-Related Infections - microbiology, Prosthesis-Related Infections - surgery, Rats, Rats, Sprague-Dawley, Staphylococcal Infections, Staphylococcal Infections - drug therapy, Staphylococcal Infections - microbiology, Staphylococcal Infections - surgery, Staphylococcus aureus, Titanium - pharmacology