Details

Autor(en) / Beteiligte

• Ding, Xiaoyun
• Peng, Zhangli
• Lin, Sz-Chin Steven
• Geri, Michela
• Li, Sixing
• Li, Peng
• Chen, Yuchao
• Dao, Ming
• Suresh, Subra
• Huang, Tony Jun

Titel

Cell separation using tilted-angle standing surface acoustic waves

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (36), p.12992-12997

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Significance We have developed a unique approach for the separation of particles and biological cells through standing surface acoustic waves oriented at an optimum angle to the fluid flow direction in a microfluidic device. This experimental setup, optimized by systematic analyses, has been used to demonstrate effective separation based on size, compressibility, and mechanical properties of particles and cells. The potential of this method for biological–biomedical applications was demonstrated through the example of isolating MCF-7 breast cancer cells from white blood cells. The method offers a possible route for label-free particle or cell separation for many applications in research, disease diagnosis, and drug-efficacy assessment.