Details

Autor(en) / Beteiligte

• Kikuchi, Tatsuya
• Okamura, Toshimitsu
• Wakizaka, Hidekatsu
• Okada, Maki
• Odaka, Kenichi
• Yui, Joji
• Tsuji, Atsushi B
• Fukumura, Toshimitsu
• Zhang, Ming-Rong

Titel

OAT3-Mediated Extrusion of the 99mTc-ECD Metabolite in the Mouse Brain

Ist Teil von

• Journal of cerebral blood flow and metabolism, 2014-04, Vol.34 (4), p.585-588

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• After administration of the 99mTc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester (99mTc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the involvement of metabolite extrusion by organic anion transporter 3 (OAT3), which is highly expressed at the blood–brain barrier in mice, in this species difference. The efflux rate of radioactivity in the cerebrum of Oat3−/− mice at later phase was 20% of that of control mice. Thus, organic anion transporters in mouse brain would be involved in the low brain retention of radioactivity after 99mTc-ECD administration.