Nucleus (Austin, Tex.), 2012-09, Vol.3 (5), p.422-428
2012
Details
- Autor(en) / Beteiligte
- Titel
- Heat-shock stress activates a novel nuclear import pathway mediated by Hikeshi
- Ist Teil von
- Nucleus (Austin, Tex.), 2012-09, Vol.3 (5), p.422-428
- Ort / Verlag
- United States: Taylor & Francis
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek (Open access)
- Beschreibungen/Notizen
- Cellular stresses significantly affect nuclear transport systems. Nuclear transport pathways mediated by importin β-family members, which are active under normal conditions, are downregulated. During thermal stress, a nuclear import pathway mediated by a novel carrier, which we named Hikeshi, becomes active. Hikeshi is not a member of the importin β family and mediates the nuclear import of Hsp70s. Unlike importin β family-mediated nuclear transport, the Hikeshi-mediated nuclear import of Hsp70s is not coupled to the GTPase cycle of the small GTPase Ran but rather is coupled with the ATPase cycle of Hsp70s. Hikeshi-mediated nuclear import is essential for the attenuation and reversal of the thermal stress response in human cells. The mechanism and functions of this newly identified nuclear import pathway will be discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1949-1034eISSN: 1949-1042DOI: 10.4161/nucl.21713Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3474662
- Format
- –
- Schlagworte
- Active Transport, Cell Nucleus, Binding, Biology, Bioscience, Calcium, Cancer, Carrier Proteins - metabolism, Cell, Cell Nucleus - metabolism, Cycle, Extra View, heat shock stress, Heat-Shock Response, HeLa Cells, Hikeshi, Hsp70, HSP70 Heat-Shock Proteins - antagonists & inhibitors, HSP70 Heat-Shock Proteins - genetics, HSP70 Heat-Shock Proteins - metabolism, Humans, Importin, Landes, molecular chaperone, nuclear transport, Organogenesis, Protein Binding, Proteins, ran GTP-Binding Protein - metabolism, RNA Interference, RNA, Small Interfering - metabolism