Genes & development, 1998-05, Vol.12 (9), p.1260-1268
1998
Details
- Autor(en) / Beteiligte
- Titel
- osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
- Ist Teil von
- Genes & development, 1998-05, Vol.12 (9), p.1260-1268
- Ort / Verlag
- United States: Cold Spring Harbor Laboratory Press
- Erscheinungsjahr
- 1998
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent and adult OPG-/- mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bone porosity, marked thinning of the parietal bones of the skull, and a high incidence of fractures. These findings demonstrate that OPG is a critical regulator of postnatal bone mass. Unexpectedly, OPG-deficient mice also exhibit medial calcification of the aorta and renal arteries, suggesting that regulation of OPG, its signaling pathway, or its ligand(s) may play a role in the long observed association between osteoporosis and vascular calcification.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0890-9369eISSN: 1549-5477DOI: 10.1101/gad.12.9.1260Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_316769
- Format
- –
- Schlagworte
- Animals, Arteries - pathology, Bone Density - genetics, Bone Density - physiology, Calcinosis - etiology, Calcinosis - pathology, Disease Models, Animal, Female, Gene Targeting, Glycoproteins - deficiency, Glycoproteins - genetics, Glycoproteins - physiology, In Situ Hybridization, Male, Mice, Mice, Knockout, Osteoporosis - etiology, Osteoporosis - pathology, Osteoprotegerin, Receptors, Cytoplasmic and Nuclear, Receptors, Tumor Necrosis Factor, Research Paper, Vascular Diseases - etiology, Vascular Diseases - pathology