Details

Autor(en) / Beteiligte

• Herndler-Brandstetter, Dietmar
• Brunner, Stefan
• Weiskopf, Daniela
• van Rijn, Ruth
• Landgraf, Katja
• Dejaco, Christian
• Duftner, Christina
• Schirmer, Michael
• Kloss, Frank
• Gassner, Robert
• Lepperdinger, Günter
• Grubeck-Loebenstein, Beatrix

Titel

Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to interleukin-15

Ist Teil von

• Human immunology, 2011-08, Vol.72 (8), p.627-631

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Abstract Immunologic memory is a critical feature of the adaptive immune system to fight recurrent infections. However, the mechanisms that shape the composition and function of the human memory T-cell pool remain incompletely understood. We here demonstrate that post-thymic human T-cell differentiation was associated with the downregulation, but not loss, of the inhibitory molecule CD5. The sensitivity of human CD8+ and CD4+ memory T cells to interleukin (IL)–15 was inversely associated with the level of CD5 expression. CD5 expression was downregulated by IL-15–mediated signaling in vitro and CD5lo memory T cells accumulated in the bone marrow. Persistent antigenic stimulation, as in the case of cytomegalovirus infection and rheumatoid arthritis (RA), was also associated with an increased number of CD5lo memory T cells. In conclusion, CD5 may be a useful marker to identify memory T-cell subsets with distinct responsiveness to the homeostatic cytokine IL-15.