Cancer cell, 2007-08, Vol.12 (2), p.115-130
- Annunziata, Christina M.
- Davis, R. Eric
- Demchenko, Yulia
- Bellamy, William
- Gabrea, Ana
- Zhan, Fenghuang
- Lenz, Georg
- Hanamura, Ichiro
- Wright, George
- Xiao, Wenming
- Dave, Sandeep
- Hurt, Elaine M.
- Tan, Bruce
- Zhao, Hong
- Stephens, Owen
- Santra, Madhumita
- Williams, David R.
- Dang, Lenny
- Barlogie, Bart
- Shaughnessy, John D.
- Kuehl, W. Michael
- Staudt, Louis M.
2007
Details
- Autor(en) / Beteiligte
- Annunziata, Christina M.
- Davis, R. Eric
- Demchenko, Yulia
- Bellamy, William
- Gabrea, Ana
- Zhan, Fenghuang
- Lenz, Georg
- Hanamura, Ichiro
- Wright, George
- Xiao, Wenming
- Dave, Sandeep
- Hurt, Elaine M.
- Tan, Bruce
- Zhao, Hong
- Stephens, Owen
- Santra, Madhumita
- Williams, David R.
- Dang, Lenny
- Barlogie, Bart
- Shaughnessy, John D.
- Kuehl, W. Michael
- Staudt, Louis M.
- Titel
- Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma
- Ist Teil von
- Cancer cell, 2007-08, Vol.12 (2), p.115-130
- Ort / Verlag
- Elsevier Inc
- Erscheinungsjahr
- 2007
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Mechanisms of constitutive NF-κB signaling in multiple myeloma are unknown. An inhibitor of IκB kinase β (IKKβ) targeting the classical NF-κB pathway was lethal to many myeloma cell lines. Several cell lines had elevated expression of NIK due to genomic alterations or protein stabilization, while others had inactivating mutations of TRAF3; both kinds of abnormality triggered the classical and alternative NF-κB pathways. A majority of primary myeloma patient samples and cell lines had elevated NF-κB target gene expression, often associated with genetic or epigenetic alteration of NIK, TRAF3, CYLD, BIRC2/ BIRC3, CD40, NFKB1, or NFKB2. These data demonstrate that addiction to the NF-κB pathway is frequent in myeloma and suggest that IKKβ inhibitors hold promise for the treatment of this disease.