Details

Autor(en) / Beteiligte

• Cohen, Robert A
• Bayliss, George
• Crispin, Jose C
• Kane-Wanger, Gwen F
• Van Beek, Christine A
• Kyttaris, Vasileios C
• Avalos, Ingrid
• Yu, C. Yung
• Tsokos, George C
• Stillman, Isaac E

Titel

T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis

Ist Teil von

• Clinical immunology (Orlando, Fla.), 2008-07, Vol.128 (1), p.1-7

Ort / Verlag

San Diego, CA: Elsevier Inc

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract We discuss a 53-year-old woman with systemic lupus erythematosus who presented with vasculitis, hypocomplementemia and nephritis. Although her serum complement 4 (C4) levels were zero, she had four copies of C4 gene. Renal biopsy revealed membranoproliferative glomerulonephritis and the presence of cryoglobulins, detected by electron microscopy, and significant numbers of T cells in the interstitium. Cryoglobulins were considered responsible for the complete consumption of C4 in the serum the levels of which improved gradually after treatment. T cells in the kidney were found to express CD44 and phosphorylated ezrin/radixin/moiesin which explain why they homed to the kidney inappropriately. The contribution of cryoglobulins and T cells in the expression of kidney pathology is discussed.