Journal of clinical pathology, 2007-06, Vol.60 (6), p.709-714
2007
Details
- Autor(en) / Beteiligte
- Titel
- Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis
- Ist Teil von
- Journal of clinical pathology, 2007-06, Vol.60 (6), p.709-714
- Ort / Verlag
- London: BMJ Publishing Group Ltd and Association of Clinical Pathologists
- Erscheinungsjahr
- 2007
- Link zum Volltext
- Quelle
- BMJ Journals Archiv - DFG Nationallizenzen
- Beschreibungen/Notizen
- Background: Pax-5 belongs to the Pax gene family transcription factors that play an important role in organogenesis and in B cell ontogeny. It is expressed in B cell non-Hodgkin’s lymphoma (B-NHL), Hodgkin’s lymphoma (HL) and neuroendocrine carcinomas. However, its expression in other tumour types is not fully explored. Aims and methods: To determine Pax-5 expression in other tumour types, immunohistochemistry was performed on 3758 benign and malignant tumours using multiple tumour microarrays, as well as on whole sections. Results: Pax-5 was expressed in 108/118 (91.5%) B-NHLs, in 60/70 (85.7%) HLs and in 0/7 T cell lymphomas. In addition, Pax-5 was seen in 24/34 (70.6%) Merkel cell carcinomas, 42/53 (79.2%) small cell carcinomas, 1/164 (0.6%) breast carcinomas, 2/204 (1%) endometrial adenocarcinomas and 1/452 (0.2%) urothelial carcinoma of the bladder. Conclusion: Despite its expression in a small subset of malignancies of epithelial origin, Pax-5 is still a good and reliable immunomarker in diagnosing B-NHL, HL and neuroendocrine carcinomas.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9746eISSN: 1472-4146DOI: 10.1136/jcp.2006.039917Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1955074
- Format
- –
- Schlagworte
- Biological and medical sciences, Biomarkers, Tumor - metabolism, Bladder, Carcinoma, Merkel Cell - diagnosis, Carcinoma, Merkel Cell - metabolism, Carcinoma, Squamous Cell - diagnosis, Carcinoma, Squamous Cell - metabolism, Diagnosis, Differential, Hodgkin Disease - diagnosis, Hodgkin Disease - metabolism, Hodgkin’s lymphoma, Humans, IHC, Immunoenzyme Techniques, immunohistochemistry, Investigative techniques, diagnostic techniques (general aspects), Lung Neoplasms - diagnosis, Lung Neoplasms - metabolism, Lymphoma, Lymphoma, Non-Hodgkin - diagnosis, Lymphoma, Non-Hodgkin - metabolism, MCC, Medical sciences, Merkel cell carcinoma, Neoplasm Proteins - metabolism, Neoplasms - diagnosis, Neoplasms - metabolism, Neuroblastoma, NHL, non-Hodgkin’s lymphoma, Original, pair box, Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques, PAX, PAX5 Transcription Factor - metabolism, Protein Array Analysis - methods, Proteins, reverse transcriptase, Rodents, SCC, small cell carcinoma, Studies, Tumors, urothelial carcinoma