Details

Autor(en) / Beteiligte

• Paul, R G
• Avery, N C
• Slatter, D A
• Sims, T J
• Bailey, A J

Titel

Isolation and characterization of advanced glycation end products derived from the in vitro reaction of ribose and collagen

Ist Teil von

• Biochemical journal, 1998-03, Vol.330 ( Pt 3) (3), p.1241-1248

Ort / Verlag

England

Erscheinungsjahr

1998

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• An amino acid component, NFC-1, when formed in vitro by the reaction of ribose and protein was shown to comprise a complex mixture of high and low molecular AGE compounds. Two low-molecular-weight components have been successfully isolated and their structure determined. These were alphaNFC-1 [Ndelta-(4-oxo-5-dihydroimidazol-2-yl)-l-ornithine] and betaNFC-1 a 4-imidazolon-2-yl derivative existing in three tautomeric forms. These imidazolone compounds have been shown to originate from the reaction of arginine with glyoxal and methylglyoxal, respectively. A third ninhydrin-positive AGE, gammaNFC-1, was shown to be composed of a number of chromatographically similar compounds which have not yet been characterized.