Details

Autor(en) / Beteiligte

• Otto, Carolin
• Schwarz, Tatjana
• Jeworowski, Lara M
• Schmidt, Marie L
• Walper, Felix
• Pache, Florence
• Schindler, Patrick
• Niederschweiberer, Moritz
• Krumbholz, Andi
• Rose, Ruben
• Drosten, Christian
• Ruprecht, Klemens
• Corman, Victor M

Titel

Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations

Ist Teil von

• Multiple sclerosis, 2023-06, Vol.29 (7), p.884-888

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective: To analyze anti-SARS-CoV-2-S1-IgG levels, avidity, Omicron BA.2 variant neutralizing capacity, and SARS-CoV-2-specific T cells in anti-CD20-treated patients with multiple sclerosis (aCD20pwMS) after two, three, or four COVID-19 vaccinations. Results: Frequencies of aCD20pwMS with detectable SARS-CoV-2-S1-IgG increased moderately between two (31/61 (51%)), three (31/57 (54%)), and four (17/26 (65%)) vaccinations. However, among patients with detectable SARS-CoV-2-S1-IgG, frequencies of high avidity (6/31 (19%) vs 11/17 (65%)) and Omicron neutralizing antibodies (0/10 (0%) vs 6/10 (60%)) increased strongly between two and four vaccinations. SARS-CoV-2-specific T cells were detectable in >92% after two or more vaccinations Conclusion: Additional vaccinations qualitatively improve SARS-CoV-2 antibody responses.