Details

Autor(en) / Beteiligte

• Ellison, R A
• Kotsonis, F N

Titel

T-2 toxin as an emetic factor in moldy corn

Ist Teil von

• Applied microbiology, 1973-10, Vol.26 (4), p.540-543

Ort / Verlag

United States

Erscheinungsjahr

1973

Quelle

MEDLINE

Beschreibungen/Notizen

• Extracts of Fusarium poae (NRRL 3287) grown either on sterile corn at 8 C or in Richards solution at room temperature were shown to have emetic activity in pigeons at nonlethal concentration under conditions of oral and intravenous administration. The causative agent was found to be T-2 toxin (3-hydroxy-4,15-diacetoxy-8-[3-methylbutyryloxy]-12,13-epoxy-Delta(9)-trichothecene). Oral and intravenous mean toxic dose values for this compound were found to be 0.72 and 0.15 mg/kg, respectively, as compared with an oral mean lethal dose of 2.75 mg/kg. The fact that T-2 toxin causes emesis at nonlethal concentrations may explain, at least in part, the observance of vomiting as a symptom resulting from ingestion of cereal grains infected with toxic Fusarium species containing T-2 or a similar toxin.