Details

Autor(en) / Beteiligte

• Liu, Lijun
• Michowski, Wojciech
• Kolodziejczyk, Aleksandra
• Sicinski, Piotr

Titel

The cell cycle in stem cell proliferation, pluripotency and differentiation

Ist Teil von

• Nature cell biology, 2019-09, Vol.21 (9), p.1060

Ort / Verlag

England

Erscheinungsjahr

2019

Link zum Volltext

Beschreibungen/Notizen

• Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. We focus on embryonic stem cells, induced pluripotent stem cells and embryonic neural stem/progenitor cells.