Details

Autor(en) / Beteiligte

• McCormack, Mark
• Gui, Hongsheng
• Ingason, Andrés
• Speed, Doug
• Wright, Galen E B
• Zhang, Eunice J
• Secolin, Rodrigo
• Yasuda, Clarissa
• Kwok, Maxwell
• Wolking, Stefan
• Becker, Felicitas
• Rau, Sarah
• Avbersek, Andreja
• Heggeli, Kristin
• Leu, Costin
• Depondt, Chantal
• Sills, Graeme J
• Marson, Anthony G
• Auce, Pauls
• Brodie, Martin J
• Francis, Ben
• Johnson, Michael R
• Koeleman, Bobby P C
• Striano, Pasquale
• Coppola, Antonietta
• Zara, Federico
• Kunz, Wolfram S
• Sander, Josemir W
• Lerche, Holger
• Klein, Karl Martin
• Weckhuysen, Sarah
• Krenn, Martin
• Gudmundsson, Lárus J
• Stefánsson, Kári
• Krause, Roland
• Shear, Neil
• Ross, Colin J D
• Delanty, Norman
• Pirmohamed, Munir
• Carleton, Bruce C
• Cendes, Fernando
• Lopes-Cendes, Iscia
• Liao, Wei-Ping
• O'Brien, Terence J
• Sisodiya, Sanjay M
• Cherny, Stacey
• Kwan, Patrick
• Baum, Larry
• Cavalleri, Gianpiero L

Titel

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients

Ist Teil von

• Neurology, 2018-01, Vol.90 (4), p.e332

Ort / Verlag

United States

Erscheinungsjahr

2018

Link zum Volltext

Beschreibungen/Notizen

• To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed. We report an association between a rare variant in the complement factor H-related 4 ( ) gene and phenytoin-induced MPE in Europeans ( = 4.5 × 10 ; odds ratio [95% confidence interval] 7 [3.2-16]). This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H ( ) gene. In addition, our results reinforce the association between and carbamazepine hypersensitivity. We did not identify significant genetic associations with MPE among Han Chinese patients. The identification of genetic predictors of MPE in CFHR4 and CFH, members of the complement factor H-related protein family, suggest a new link between regulation of the complement system alternative pathway and phenytoin-induced hypersensitivity in European-ancestral patients.