Details

Autor(en) / Beteiligte

• Roager, Henrik M
• Hansen, Lea B S
• Bahl, Martin I
• Frandsen, Henrik L
• Carvalho, Vera
• Gøbel, Rikke J
• Dalgaard, Marlene D
• Plichta, Damian R
• Sparholt, Morten H
• Vestergaard, Henrik
• Hansen, Torben
• Sicheritz-Pontén, Thomas
• Nielsen, H Bjørn
• Pedersen, Oluf
• Lauritzen, Lotte
• Kristensen, Mette
• Gupta, Ramneek
• Licht, Tine R

Titel

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Ist Teil von

• Nature microbiology, 2016-06, Vol.1 (9), p.16093

Ort / Verlag

England

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.