Nature methods, 2016-05, Vol.13 (5), p.435
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Strain-level microbial epidemiology and population genomics from shotgun metagenomics
- Ist Teil von
- Nature methods, 2016-05, Vol.13 (5), p.435
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Identifying microbial strains and characterizing their functional potential is essential for pathogen discovery, epidemiology and population genomics. We present pangenome-based phylogenomic analysis (PanPhlAn; http://segatalab.cibio.unitn.it/tools/panphlan), a tool that uses metagenomic data to achieve strain-level microbial profiling resolution. PanPhlAn recognized outbreak strains, produced the largest strain-level population genomic study of human-associated bacteria and, in combination with metatranscriptomics, profiled the transcriptional activity of strains in complex communities.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1548-7105DOI: 10.1038/nmeth.3802Titel-ID: cdi_pubmed_primary_26999001
- Format
- –
- Schlagworte
- Escherichia coli - classification, Escherichia coli - genetics, Escherichia coli - isolation & purification, Escherichia coli - pathogenicity, Gene Expression Profiling, Genome, Bacterial, Germany, Humans, Intestinal Mucosa - microbiology, Metagenome - genetics, Metagenomics - methods, Microbial Consortia - genetics, Phylogeny, Skin - microbiology, Software, Species Specificity