Details

Autor(en) / Beteiligte

• Mabray, Marc C
• Lillaney, Prasheel
• Sze, Chia-Hung
• Losey, Aaron D
• Yang, Jeffrey
• Kondapavulur, Sravani
• Liu, Derek
• Saeed, Maythem
• Patel, Anand
• Cooke, Daniel
• Jun, Young-Wook
• El-Sayed, Ivan
• Wilson, Mark
• Hetts, Steven W

Titel

In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study

Ist Teil von

• Journal of vascular and interventional radiology, 2016-03, Vol.27 (3), p.426

Ort / Verlag

United States

Erscheinungsjahr

2016

Link zum Volltext

Beschreibungen/Notizen

• To establish that a magnetic device designed for intravascular use can bind small iron particles in physiologic flow models. Uncoated iron oxide particles 50-100 nm and 1-5 µm in size were tested in a water flow chamber over a period of 10 minutes without a magnet (ie, control) and with large and small prototype magnets. These same particles and 1-µm carboxylic acid-coated iron oxide beads were likewise tested in a serum flow chamber model without a magnet (ie, control) and with the small prototype magnet. Particles were successfully captured from solution. Particle concentrations in solution decreased in all experiments (P < .05 vs matched control runs). At 10 minutes, concentrations were 98% (50-100-nm particles in water with a large magnet), 97% (50-100-nm particles in water with a small magnet), 99% (1-5-µm particles in water with a large magnet), 99% (1-5-µm particles in water with a small magnet), 95% (50-100-nm particles in serum with a small magnet), 92% (1-5-µm particles in serum with a small magnet), and 75% (1-µm coated beads in serum with a small magnet) lower compared with matched control runs. This study demonstrates the concept of magnetic capture of small iron oxide particles in physiologic flow models by using a small wire-mounted magnetic filter designed for intravascular use.