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Maintaining system homeostasis: the third law of Newtonian immunology
Ist Teil von
Nature immunology, 2012-10, Vol.13 (10), p.902
Ort / Verlag
United States
Erscheinungsjahr
2012
Link zum Volltext
Beschreibungen/Notizen
Because of the potent effector mechanisms of the immune system, the potential for self-destructive immune responses is especially high and many negative regulatory modalities exist to prevent excessive tissue damage. This Commentary places such regulatory mechanisms in the larger context of system organization on many scales. The sometimes counterintuitive nature of feedback control is discussed and a case is made for greater attention to quantitative spatiotemporal aspects of regulation, rather than limiting the discussion to the qualitative descriptions of pathways that dominate at present.