Details

Autor(en) / Beteiligte

• Aerts, Hugo J W L
• van Baardwijk, Angela A W
• Petit, Steven F
• Offermann, Claudia
• Loon, Judith van
• Houben, Ruud
• Dingemans, Anne-Marie C
• Wanders, Rinus
• Boersma, Liesbeth
• Borger, Jacques
• Bootsma, Gerben
• Geraedts, Wiel
• Pitz, Cordula
• Simons, Jean
• Wouters, Bradly G
• Oellers, Michel
• Lambin, Philippe
• Bosmans, Geert
• Dekker, Andre L A J
• De Ruysscher, Dirk

Titel

Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy (18)Fluorodeoxyglucose-PET-CT scan

Ist Teil von

• Radiotherapy and oncology, 2009-06, Vol.91 (3), p.386

Ort / Verlag

Ireland

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Non-small cell lung cancer (NSCLC) tumours are mostly heterogeneous. We hypothesized that areas within the tumour with a high pre-radiation (18)F-deoxyglucose (FDG) uptake, could identify residual metabolic-active areas, ultimately enabling selective-boosting of tumour sub-volumes. Fifty-five patients with inoperable stage I-III NSCLC treated with chemo-radiation or with radiotherapy alone were included. For each patient one pre-radiotherapy and one post-radiotherapy FDG-PET-CT scans were available. Twenty-two patients showing persistent FDG uptake in the primary tumour after radiotherapy were analyzed. Overlap fractions (OFs) were calculated between standardized uptake value (SUV) threshold-based auto-delineations on the pre- and post-radiotherapy scan. Patients with residual metabolic-active areas within the tumour had a significantly worse survival compared to individuals with a complete metabolic response (p=0.002). The residual metabolic-active areas within the tumour largely corresponded (OF>70%) with the 50%SUV high FDG uptake area of the pre-radiotherapy scan. The hotspot within the residual area (90%SUV) was completely within the GTV (OF=100%), and had a high overlap with the pre-radiotherapy 50%SUV threshold (OF>84%). The location of residual metabolic-active areas within the primary tumour after therapy corresponded with the original high FDG uptake areas pre-radiotherapy. Therefore, a single pre-treatment FDG-PET-CT scan allows for the identification of residual metabolic-active areas.