Details

Autor(en) / Beteiligte

• Mencarelli, C
• Magi, B
• Marzocchi, B
• Armellini, D
• Pallini, V

Titel

Evolution of the "titin epitope" in neurofilament proteins

Ist Teil von

• Comparative biochemistry and physiology. B, Comparative biochemistry, 1991, Vol.100 (4), p.741

Ort / Verlag

England

Erscheinungsjahr

1991

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• 1. The specificity of a monoclonal antibody raised to human titin was characterized. The antibody reacts with an epitope which is common to titin and the high mol. wt subunits NF-H and NF-M of mammalian neurofilaments. 2. Mapping of the epitope indicated that it is located in the carboxyterminal extension of NF-H and NF-M, and that its reactivity does not depend on the phosphorylation state of the molecule. 3. A comparative study on neurofilament protein of lower vertebrates revealed that this epitope has been conserved during vertebrate evolution.