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Laser diffraction is probably the most widely used technique for particle-size analysis in the pharmaceutical industry, with applications from drug development to production and quality control. The nature of particle-size analysis in terms of how particle size itself is defined and how measurements should be controlled, however, is seldom discussed. This article reviews the laser diffraction technique, addressing the concerns that have been expressed. Although it is recognized that laser diffraction may not be the method of choice for every particle-sizing application, misuse of the technique is to blame for some of the poor comparisons that have been made against other methods of analysis. Laser diffraction can provide precise, rapid results as long as sampling and dispersion are controlled and the requirements of the analysis are correctly understood.