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Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile
Ist Teil von
Lasers in medical science, 2012-03, Vol.27 (2), p.389-395
Ort / Verlag
London: Springer-Verlag
Erscheinungsjahr
2012
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The aim of this trial was to investigate changes occurring in the subgingival microbiological composition of subjects with aggressive periodontitis, treated with antimicrobial photodynamic therapy (aPDT), in a single episode, or scaling and root planing (SRP), in a split-mouth design on −7, 0, and +90 days. Ten patients were randomly assigned to either aPDT using a laser source in conjunction with a photosensitizer or SRP with hand instruments. Subgingival plaque samples were collected and the counts of 40 subgingival species were determined using checkerboard DNA-DNA hybridization. The data were analyzed using the method of generalized estimating equations (GEE) to test the associations between treatments, evaluated parameters, and experimental times (α = .05). The results indicated that aPDT and SRP affects different bacterial species, with aPDT being effective in reducing numbers of
A. actinomycetemcomitans
than SRP. On the other hand, SRP was more efficient than aPDT in reducing the presence of periodontal pathogens of the
Red Complex
. Additionally, a recolonization in the sites treated by aPDT was observed, especially for
T. forsythia
and
P. gingivalis.
Under our experimental conditions, this trial demonstrates that aPDT and SRP affected different groups of bacteria, suggesting that their association may be beneficial for the non-surgical treatment of aggressive periodontitis.