Science (American Association for the Advancement of Science), 2011-05, Vol.332 (6030), p.729-732
2011
Details
- Autor(en) / Beteiligte
- Titel
- Neuronal GPCR Controls Innate Immunity by Regulating Noncanonical Unfolded Protein Response Genes
- Ist Teil von
- Science (American Association for the Advancement of Science), 2011-05, Vol.332 (6030), p.729-732
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway required for innate immunity in Caenorhabditis elegans. OCTR-1, a putative octopamine G protein—coupled catecholamine receptor (GPCR, G protein—coupled receptor), functioned in sensory neurons designated ASH and ASI to actively suppress innate immune responses by down-regulating the expression of noncanonical UPR genes pqn/abu in nonneuronal tissues. Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1203411Titel-ID: cdi_proquest_miscellaneous_907933954
- Format
- –
- Schlagworte
- Adult animals, Anatomy, Animals, Bacterial Load, Biological and medical sciences, Caenorhabditis elegans, Caenorhabditis elegans - genetics, Caenorhabditis elegans - immunology, Caenorhabditis elegans - microbiology, Caenorhabditis elegans Proteins - genetics, Caenorhabditis elegans Proteins - metabolism, Caenorhabditis elegans Proteins - physiology, Double stranded RNA, Down-Regulation, Endoplasmic Reticulum - metabolism, Feedback (Response), Fundamental and applied biological sciences. Psychology, Fundamental immunology, Gene expression regulation, Genes, Genes, Helminth, Genetic mutation, Genetics of the immune response, Immunity, Innate, Immunobiology, Innate immunity, Intestines - metabolism, Membrane Proteins - genetics, Membrane Proteins - metabolism, Mitogen-Activated Protein Kinases - genetics, Mitogen-Activated Protein Kinases - metabolism, Mutation, Nervous system diseases, Neurodegenerative diseases, Neurons, Pathogens, Pharynx - metabolism, Pseudomonas aeruginosa - immunology, Pseudomonas aeruginosa - pathogenicity, Receptors, G-Protein-Coupled - genetics, Receptors, G-Protein-Coupled - physiology, Sensory Receptor Cells - physiology, Signal Transduction, Stress, Physiological, Transcription, Genetic, Unfolded Protein Response - genetics, Up-Regulation