Details

Autor(en) / Beteiligte

• Eyerich, Kilian
• Eyerich, Stefanie
• Onken, Anna T
• Weidinger, Stephan
• Franke, Andre
• Nasorri, Francesca
• Pennino, Davide
• Grosber, Martine
• Pfab, Florian
• Schmidt-Weber, Carsten B
• Mempel, Martin
• Hein, Ruediger
• Ring, Johannes
• Cavani, Andrea

Titel

Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema

Ist Teil von

• The New England journal of medicine, 2011-07, Vol.365 (3), p.231-238

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The skin infiltrates of atopic eczema consist predominantly of type 2 helper T cells, whereas those of psoriasis are mainly types 1 and 17. The two diseases are elicited by different types of antigens and are largely mutually exclusive, since one type of infiltrate antagonizes the other. Psoriasis and atopic eczema are prevalent, influence health-related quality of life, are associated with concomitant illness, and pose an economic burden. Whether these diseases are epithelial or immunologic disorders is debated. Both involve complex interactions of hereditary factors and environmental influences. Besides altering the skin barrier, these conditions lead to a systemic T-cell–driven immune response with primary involvement of not only the skin but also other sites such as joints (in psoriatic arthritis) or airways (in asthma and rhinitis). Whereas atopic eczema arises from a systemic Th2-cell–dominated immune shift characterized by frequent elevations of total and allergen-specific IgE levels, 1 psoriasis . . .