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X-chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non-Amerindian populations
American journal of human biology, 2011-05, Vol.23 (3), p.299-304
Amorim, Carlos Eduardo G.
Wang, Sijia
Marrero, Andrea R.
Salzano, Francisco M.
Ruiz-Linares, Andrés
Bortolini, Maria Cátira
2011
Details
Autor(en) / Beteiligte
Amorim, Carlos Eduardo G.
Wang, Sijia
Marrero, Andrea R.
Salzano, Francisco M.
Ruiz-Linares, Andrés
Bortolini, Maria Cátira
Titel
X-chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non-Amerindian populations
Ist Teil von
American journal of human biology, 2011-05, Vol.23 (3), p.299-304
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Objectives: We report X‐chromosomal linkage disequilibrium (LD) patterns in Amerindian (Kogi, Wayuu, and Zenu) and admixed Latin American (Central Valley of Costa Rica and Southern Brazilian Gaucho) populations. Methods: Short tandem repeats (STRs) widespread along the X‐chromosome were investigated in 132 and 124 chromosomes sampled from the Amerindian tribes and the admixed Latin American populations, respectively. Diversity indexes (gene diversity and average numbers of alleles per locus) were estimated for each population and the level of LD was inferred with an exact test. Results: The Amerindian populations presented lower genetic diversity and a higher proportion of loci in LD than the admixed ones. Two haplotype blocks were identified in the X‐chromosome, both restricted to the Amerindians. The first involved DXS8051 and DXS7108 in Xp22.22 and Xp22.3, while the second found only among the Kogi, included eight loci in a region between Xp11.4 and Xq21.1. Conclusions: In accordance to previous work done with other populations, human isolates, such as Amerindian tribes, seem to be an optimal choice for the implementation of association studies due to the wide extent of LD which can be found in their gene pool. On the other hand, the low proportion of loci in LD found in both admixed populations studied here could be explained by events related to their history and similarities between the allele frequencies in the parental stocks. Am. J. Hum. Biol., 2011. © 2011 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1042-0533
eISSN: 1520-6300
DOI: 10.1002/ajhb.21110
Titel-ID: cdi_proquest_miscellaneous_861789169
Format
–
Schlagworte
Brazil
,
Chromosomes, Human, X - genetics
,
Colombia
,
Costa Rica
,
European Continental Ancestry Group - genetics
,
Female
,
Gene Frequency
,
Genetic Variation
,
Haplotypes
,
Humans
,
Indians, Central American - genetics
,
Indians, South American - genetics
,
Linkage Disequilibrium
,
Male
,
Microsatellite Repeats
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