Details

Autor(en) / Beteiligte

• Michel, Laure, MD
• Toulgoat, Frédérique, MD
• Desal, Hubert, MD, PhD
• Laplaud, David Axel, MD, PhD
• Magot, Armelle, MD
• Hamidou, Mohamed, MD
• Wiertlewski, Sandrine, MD

Titel

Atypical Neurologic Complications in Patients with Primary Sjögren's Syndrome: Report of 4 Cases

Ist Teil von

• Seminars in arthritis and rheumatism, 2011-02, Vol.40 (4), p.338-342

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Background Neurologic involvement occurs in approximately 25% of patients with primary Sjögren's syndrome. Manifestations are diverse and can affect the entire neuroaxis. Central nervous system dysfunction involves the brain as well as the spinal cord and may recur over time. Due to a variety of presentations, Sjögren's syndrome with neurologic involvement may be difficult to diagnose. Methods We report 4 cases of patients with primary Sjögren's syndrome who presented with atypical neurologic manifestations. Results The first case describes a patient with a pseudotumoral lesion. The second patient was a 54-year-old woman suffering from a multiple mononeuropathy. The third case describes a 66-year-old man whose primary Sjögren's syndrome presented as progressive multiple sclerosis, and the fourth case reports a 57-year-old woman patient suffering from myelitis along with progressive cognitive disorders. Conclusions Neurologic impairment in Sjögren's syndrome is probably underestimated and the diagnosis is often delayed. Primary Sjögren's syndrome should be suspected in patients presenting with atypical clinical and radiologic neurologic manifestations.