Details

Autor(en) / Beteiligte

• König, W
• Geiger, R
• Wissmann, H
• Bickel, M
• Obermeier, R
• Teetz, W
• Uhmann, R

Titel

Chemical and biological properties of porcine secretin and secretin analogues modified in positions 3 and 4

Ist Teil von

• Gastroenterology (New York, N.Y. 1943), 1977-04, Vol.72 (4 Pt.2), p.797-800

Ort / Verlag

United States

Erscheinungsjahr

1977

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The synthesis of secretin does not offer fundamental difficulties any longer. The problem of the stability of the hormone seems to be solved from a practical point of view. However, the mechanism of the inactivation of secretin in solution is not yet satisfactorily explained, alpha-beta Rearrangement of the Asp-Gly bond may play a role, but some observations indicate that inactivation is not a straight reaction. Like secretion [Ala-4] secretin shows beta-sympathomimetic activity. The availability of a suitable depot preparation permits physiological studies with secretin and its analogues after subcutaneous administration.