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meta-analysis of serum tumor markers in lung cancer
Ist Teil von
Zhongguo fei ai za zhi, 2010-12, Vol.13 (12), p.1136-1140
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ）
Beschreibungen/Notizen
BACKGROUND AND OBJECTIVEthe detection of serum tumor markers is of great value for early diagnosis of lung cancer. The aim of this study is to summarize the clinic significance characteristics of serum markers contributing to the detection of lung cancer. METHODSreferences about serum markers of lung cancer were estimated using meta-analysis method. 712 references which included more than 20 cases, 20 controls, the serum markers of 52 832 patients with malignancies and 32 037 patients as controls were evaluated. RESULTSoverall the detection of 13 markers play a significant part in lung cancer diagnosis. The sensitivity of CEA, CA125, CYFRA21-1, TPA, SCCAg, DKK1, NSE, ProGRP in the patients' serum with lung cancer were 47.50%, 50.11%, 57.00%, 50.93%, 49.00%, 69.50%, 39.73%, 51.48% and the specificity were 92.34%, 80.19%, 90.16%, 88.41%, 91.07%, 92.20%, 89.11%, 94.89%. In the combined analysis of tumor markers: the sensitivity, specificity of NSE+ProGRP were 88.90% and 72.82% in diagnosis of small cell lung can
Sprache
Chinesisch
Identifikatoren
eISSN: 1999-6187
DOI: 10.3779/j.issn.1009-3419.2010.12.11
Titel-ID: cdi_proquest_miscellaneous_821975290
Format
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