Details

Autor(en) / Beteiligte

• De Schutter, Erik
• Bower, James M.

Titel

Simulated Responses of Cerebellar Purkinje Cells are Independent of the Dendritic Location of Granule Cell Synaptic Inputs

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1994-05, Vol.91 (11), p.4736-4740

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

1994

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Cerebellar Purkinje cell responses to granule cell synaptic inputs were examined with a computer model including active dendritic conductances. Dendritic P-type Ca2+channels amplified postsynaptic responses when the model was firing at a physiological rate. Small synchronous excitatory inputs applied distally on the large dendritic tree resulted in somatic responses of similar size to those generated by more proximal inputs. In contrast, in a passive model the somatic postsynaptic potentials to distal inputs were 76% smaller. The model predicts that the somatic firing response of Purkinje cells is relatively insensitive to the exact dendritic location of synaptic inputs. We describe a mechanism of Ca2+-mediated synaptic amplification, based on the subspiking threshold recruitment of P-type Ca2+channels in the dendritic branches surrounding the input site.