Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Application of food and feed safety assessment principles to evaluate transgenic approaches to gene modulation in crops
Ist Teil von
Food and chemical toxicology, 2010-07, Vol.48 (7), p.1773-1790
Ort / Verlag
Oxford: Elsevier Ltd
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
New crop varieties containing traits such as enhanced nutritional profiles, increased yield, and tolerance to drought are being developed. In some cases, these new traits are dependent on small RNAs or regulatory proteins such as transcription factors (TF) that modify the expression of endogenous plant genes. To date, the food and feed safety of genetically modified (GM) crops has been assessed by the application of a set of internationally accepted procedures for evaluating the safety of GM crops. The goal of this paper is to review the main aspects of the current safety assessment paradigm and to recommend scientifically sound principles for conducting a safety assessment for GM crops that are developed by technologies that modify endogenous plant gene expression. Key considerations for such a safety assessment include the following:(1)RNA and TF are generally recognized as safe (GRAS);(2)Genes encoding RNAi and regulatory proteins such as TFs are an important component of the plant genome;(3)Crops engineered using RNAi modifications are not expected to produce heterologous proteins;(4)The modulation of TFs may result in quantitative differences in endogenous plant components, which can be assessed through agronomic performance and compositional analysis on a case-by-case basis.