Details

Autor(en) / Beteiligte

• Migliorati, Graziella
• Nicoletti, lldo
• Pagliacci, M. Cristina
• D'Adamio, Luciano
• Riccardi, Carlo

Titel

Interleukin-4 Protects Double-Negative and CD4 Single-Positive Thymocytes From Dexamethasone-Induced Apoptosis

Ist Teil von

• Blood, 1993-03, Vol.81 (5), p.1352-1358

Ort / Verlag

Washington, DC: Elsevier Inc

Erscheinungsjahr

1993

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Glucocorticoid hormones (GCH) and anti-CD3 monoclonal antibodies (MoAbs) induce in mouse thymocytes and T-cell tumor lines an active process of cell death called apoptosis. Interleukins (IL), including IL-1 and IL-2, have been reported to inhibit such apoptosis. In this study we show that IL-4 also reduced the DIMA fragmentation characteristic of dexamethasone (DEX)-induced apoptosis in thymocytes. This effect, studied in both time-course and dose-response experiments, was also detected at low IL-4 concentrations (1 U/mL) and against high DEX levels (10−7 mol/L). The effect of IL-4 was blocked by an anti-IL-4 but not by an anti-IL-1a MoAb, and was thus both specific and direct. Phenotypic analysis showed that IL-4 protects predominantly CD4−CD8− and CD4+CD8− cells. Our findings suggest that intrathymic T-cell development may be influenced by IL-4.