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Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4280-4283

2009

Autor(en) / Beteiligte

Titel

Dipeptidyl nitrile inhibitors of Cathepsin L

Ist Teil von

Ort / Verlag

Amsterdam: Elsevier Ltd

Erscheinungsjahr

2009

Link zum Volltext

Quelle

ScienceDirect Journals (5 years ago - present)

Beschreibungen/Notizen

A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.

Sprache: Englisch
Identifikatoren: ISSN: 0960-894X
eISSN: 1464-3405
DOI: 10.1016/j.bmcl.2009.05.071
Titel-ID: cdi_proquest_miscellaneous_733364332

Format: –
Schlagworte: Aggrecan, Animals, Biological and medical sciences, Bones, joints and connective tissue. Antiinflammatory agents, Cartilage, Cartilage, Articular - pathology, Catalysis, Cathepsin, Cathepsin B, Cathepsin K, Cathepsin L, Cathepsin L - antagonists & inhibitors, Cathepsin L - chemistry, Cathepsin L2, Cathepsin S, Cathepsin V, Chemistry, Pharmaceutical - methods, Collagen, Conformational lock, Covalent inhibitor, Crystallography, X-Ray - methods, Cysteine protease, Drug Design, Humans, Ligands, Medical sciences, Mice, Mice, Transgenic, Molecular pincer, Nitrile, Nitriles - chemical synthesis, Nitriles - chemistry, Nitriles - pharmacology, Osteoarthritis, Peptides - chemical synthesis, Peptides - pharmacology, Pharmacology. Drug treatments, Protein structure, Proteins - chemistry, Selectivity, Structure-Activity Relationship, Structure-based design, Tautomeric lock, X-ray crystallography

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