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Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects
Ist Teil von
The New England journal of medicine, 2003-02, Vol.348 (6), p.538-549
Ort / Verlag
Boston, MA: Massachusetts Medical Society
Erscheinungsjahr
2003
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
It is well recognized that different patients respond in different ways to the same medication. These differences are often greater among members of a population than they are within the same person at different times (or between monozygotic twins).
1
The existence of large population differences with small intrapatient variability is consistent with inheritance as a determinant of drug response; it is estimated that genetics can account for 20 to 95 percent of variability in drug disposition and effects.
2
Although many nongenetic factors influence the effects of medications, including age, organ function, concomitant therapy, drug interactions, and the nature of the . . .