Details

Autor(en) / Beteiligte

• Ubl, Andreas
• Berg, Daniela
• Holzmann, Carsten
• Krüger, Rejko
• Berger, Klaus
• Arzberger, Thomas
• Bornemann, Antje
• Riess, Olaf

Titel

14-3-3 protein is a component of Lewy bodies in Parkinson’s disease—Mutation analysis and association studies of 14-3-3 eta

Ist Teil von

• Brain research. Molecular brain research., 2002-12, Vol.108 (1), p.33-39

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2002

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Mutations in α-synuclein have been identified in some rare families with autosomal dominant Parkinson’s disease (PD). The synuclein gene family shares physical and functional homology with 14-3-3 proteins and binds to 14-3-3 proteins and to its ligands. We therefore investigated whether 14-3-3 proteins are also involved in the pathogenesis of PD. Here we demonstrate that 14-3-3 proteins are colocalized with Lewy bodies in PD. We investigated the 14-3-3 eta ( YWHAH) gene by mutation analysis and association studies as it maps to human chromosome 22q12.1–q13.1, a region which has been recently implicated in PD and carried out immunohistochemical studies of Lewy bodies with two different 14-3-3 eta antibodies. In 358 sporadic and familial PD patients, disease causing mutations were not identified. Furthermore, association studies with intragenic polymorphisms do not provide evidence for an involvement of 14-3-3 eta in the pathogenesis of PD. In accordance with these findings, there was no staining of substantia nigra Lewy bodies with antibodies specific for the 14-3-3 eta subunit.