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Details

Autor(en) / Beteiligte
Titel
Wallerian degeneration after crush or chronic constriction injury of rodent sciatic nerve is associated with a depletion of endoneurial interleukin-10 protein
Ist Teil von
  • Experimental neurology, 2004-07, Vol.188 (1), p.187-191
Ort / Verlag
Amsterdam: Elsevier Inc
Erscheinungsjahr
2004
Quelle
MEDLINE
Beschreibungen/Notizen
  • We used enzyme-linked immunoassay (ELISA), immunohistochemistry (IHC), and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to determine whether interleukin (IL)-10 protein is changed after unilateral crush or chronic constriction injury (CCI) of mouse or rat sciatic nerve and whether IL-10 protein and mRNA are differentially regulated. In the mouse sciatic nerve, IL-10 protein declined rapidly to 10–20% of baseline early after crush or CCI, while the IL10 mRNA was up-regulated with a maximum on Days 1 and 3. In the rat sciatic nerve, IL-10 protein was significantly reduced on Day 3 after CCI, and IL-10 mRNA was up-regulated in both models. These results suggest that changes of the local cytokine network during wallerian degeneration include an early deficiency of the antiinflammatory cytokine IL-10 despite up-regulation at the mRNA level.
Sprache
Englisch
Identifikatoren
ISSN: 0014-4886
eISSN: 1090-2430
DOI: 10.1016/j.expneurol.2004.02.011
Titel-ID: cdi_proquest_miscellaneous_72012952

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