Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3217-3220
- Al-awar, Rima S.
- Ray, James E.
- Hecker, Kyle A.
- Huang, Jianping
- Waid, Philip P.
- Shih, Chuan
- Brooks, Harold B.
- Spencer, Charles D.
- Watkins, Scott A.
- Patel, Bharvin R.
- Stamm, Nancy B.
- Ogg, Catherine A.
- Schultz, Richard M.
- Considine, Eileen L.
- Faul, Margaret M.
- Sullivan, Kevin A.
- Kolis, Stanley P.
- Grutsch, John L.
- Joseph, Sajan
2004
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- Autor(en) / Beteiligte
- Al-awar, Rima S.
- Ray, James E.
- Hecker, Kyle A.
- Huang, Jianping
- Waid, Philip P.
- Shih, Chuan
- Brooks, Harold B.
- Spencer, Charles D.
- Watkins, Scott A.
- Patel, Bharvin R.
- Stamm, Nancy B.
- Ogg, Catherine A.
- Schultz, Richard M.
- Considine, Eileen L.
- Faul, Margaret M.
- Sullivan, Kevin A.
- Kolis, Stanley P.
- Grutsch, John L.
- Joseph, Sajan
- Titel
- 1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3217-3220
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2004
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- A series of novel 1,7-annulated indolocarbazoles was prepared and evaluated for kinase inhibitory activity. The synthesis and kinase inhibitory activity of a series of novel 1,7-annulated indolocarbazoles 6 and 16 is described. These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2004.03.105Titel-ID: cdi_proquest_miscellaneous_71934978
- Format
- –
- Schlagworte
- Antineoplastic agents, Biological and medical sciences, Carbazoles - chemistry, Carbazoles - pharmacology, Cyclin D1 - antagonists & inhibitors, Cyclin D1 - metabolism, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases - antagonists & inhibitors, Cyclin-Dependent Kinases - metabolism, General aspects, Indoles - chemistry, Indoles - pharmacology, Medical sciences, Miscellaneous, Pharmacology. Drug treatments, Protein Kinase Inhibitors - chemistry, Protein Kinase Inhibitors - pharmacology, Proto-Oncogene Proteins - antagonists & inhibitors, Proto-Oncogene Proteins - metabolism