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Serotonin protects NK cells against oxidatively induced functional inhibition and apoptosis
Ist Teil von
Journal of leukocyte biology, 2001-07, Vol.70 (1), p.65-72
Ort / Verlag
United States: Society for Leukocyte Biology
Erscheinungsjahr
2001
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
High concentrations of the neurotransmitter serotonin can be found ininflamed and ischemic peripheral tissues, but the role of serotonin inimmunoregulation is largely unknown. Here we report that serotoninprotected human natural‐killer (NK) cells from oxidatively inducedinhibition inflicted by autologous monocytes in vitro. Serotoninprotected NK cells from monocyte‐mediated apoptosis and suppression ofcytotoxicity and maintained the activation of NK cells induced byinterleukin‐2 despite the presence of inhibitory monocytes. A detailedanalysis of these protective effects revealed that serotonin scavengedreactive oxygen species (ROS) derived from theH2O2‐myeloperoxidase (‐MPO) system. Serotoninshared this scavenger activity with its precursor, 5‐hydroxytryptophan(5‐HTP); however, serotonin was >10‐fold more potent than 5‐HTP inprotecting NK cells against functional inhibition and apoptosis. Wepropose that serotonin, by scavenging peroxidase‐derived ROS, may serveto protect NK cells from oxidative damage at inflammatory sites.