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ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis
Cytometry. Part A, 2007-05, Vol.71A (5), p.317-326
Ruth, Jeffrey H.
Rottman, James B.
Kingsbury, Gillian A.
Coyle, Anthony J.
Haines, G. Kenneth
Pope, Richard M.
Koch, Alisa E.
2007
Details
Autor(en) / Beteiligte
Ruth, Jeffrey H.
Rottman, James B.
Kingsbury, Gillian A.
Coyle, Anthony J.
Haines, G. Kenneth
Pope, Richard M.
Koch, Alisa E.
Titel
ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis
Ist Teil von
Cytometry. Part A, 2007-05, Vol.71A (5), p.317-326
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2007
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
To better define important cell subsets expressing activation markers in rheumatoid arthritis (RA), we compared selective lymphocyte and monocyte B7H1, B7H2, B7RP.1, B7RP.2, and inducible costimulatory molecule (ICOS) expression from normal peripheral blood (NL PB), RA PB, and RA synovial fluid (SF) by multicolor flow cytometry and immunohistochemistry. RA SF memory lymphocytes expressed B7RP.1 and B7RP.2, suggesting that T‐cells may function as antigen presenting cells (APCs) in RA joints. We found similar results for ICOS expression. RA SF CD14+ monocytes also expressed B7RP.1 (an ICOS ligand) and the homologous ligand B7RP.2, identifying monocytes as potential mediators of antigen processing and lymphocyte activation in RA. Furthermore, we found an increased population of RA SF CD14+ monocytes expressing B7H1 and B7H2. [The FACS analysis was supported by immunohistochemistry, showing intense lymphocyte and APC (macrophages with dendritic morphology) ICOS staining in RA synovial tissue (ST). Overall, these results define elevated populations of memoryT‐lymphocytes expressing proinflammatory B7 molecules in RA SF that either stimulate T cells through ICOS (via ICOS ligands B7RP.1 and B7RP.2), or down‐regulate RA ST T‐lymphocytes through B7H1 and B7H2.] Therefore, in the same joint, there may exist positive and negative influences on the inflammatory response, and perhaps, the negative signals dominate as joint inflammation resolves. © 2007 International Society for Analytical Cytology
Sprache
Englisch
Identifikatoren
ISSN: 1552-4922
eISSN: 1552-4930
DOI: 10.1002/cyto.a.20383
Titel-ID: cdi_proquest_miscellaneous_70388366
Format
–
Schlagworte
antigen presentation
,
Antigens, Differentiation, T-Lymphocyte - metabolism
,
Arthritis, Rheumatoid - blood
,
Arthritis, Rheumatoid - immunology
,
Arthritis, Rheumatoid - metabolism
,
Arthritis, Rheumatoid - pathology
,
B7-1 Antigen - metabolism
,
CD3 Complex - analysis
,
CD3 Complex - metabolism
,
CD4-Positive T-Lymphocytes - metabolism
,
CD8-Positive T-Lymphocytes - metabolism
,
Flow Cytometry
,
Humans
,
ICOS
,
Immunohistochemistry
,
Immunologic Memory
,
Inducible T-Cell Co-Stimulator Protein
,
inflammation
,
Leukocyte Common Antigens - metabolism
,
Lipopolysaccharide Receptors - analysis
,
Lipopolysaccharide Receptors - metabolism
,
Lymphocyte Activation
,
Lymphocyte Subsets - immunology
,
Lymphocyte Subsets - metabolism
,
Lymphocyte Subsets - pathology
,
Monocytes - metabolism
,
rheumatoid arthritis
,
Synovial Fluid
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