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Toward accurate diagnosis of white matter pathology using diffusion tensor imaging
Magnetic resonance in medicine, 2007-04, Vol.57 (4), p.688-695
Budde, Matthew D.
Kim, Joong Hee
Liang, Hsiao-Fang
Schmidt, Robert E.
Russell, John H.
Cross, Anne H.
Song, Sheng-Kwei
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Budde, Matthew D.
Kim, Joong Hee
Liang, Hsiao-Fang
Schmidt, Robert E.
Russell, John H.
Cross, Anne H.
Song, Sheng-Kwei
Titel
Toward accurate diagnosis of white matter pathology using diffusion tensor imaging
Ist Teil von
Magnetic resonance in medicine, 2007-04, Vol.57 (4), p.688-695
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2007
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Diffusion tensor imaging (DTI) has been widely applied to investigate injuries in the central nervous system (CNS) white matter (WM). However, the underlying pathological correlates of diffusion changes have not been adequately determined. In this study the coregistration of histological sections to MR images and a pixel‐based receiver operating characteristic (ROC) analysis were used to compare the axial (λ∥) and radial (λ⟂) diffusivities derived from DTI and histological markers of axon (phosphorylated neurofilament, SMI‐31) and myelin (Luxol fast blue (LFB)) integrity, respectively, in two different patterns of injury to mouse spinal cord (SC) WM. In contusion SC injury (SCI), a decrease in λ∥ matched the pattern of axonal damage with high accuracy, but λ⟂ did not match the pattern of demyelination detected by LFB. In a mouse model of multiple sclerosis (MS), λ⟂ and λ∥ did not match the patterns of demyelination or axonal damage, respectively. However, a region of interest (ROI) analysis suggested that λ⟂‐detected demyelination paralleled that observed with LFB, and λ∥ decreased in both regions of axonal damage and normal‐appearing WM (NAWM) as visualized by SMI‐31. The results suggest that directional diffusivities may reveal abnormalities that are not obvious with SMI‐31 and LFB staining, depending on the type of injury. Magn Reson Med 57:688–695, 2007. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.21200
Titel-ID: cdi_proquest_miscellaneous_70334652
Format
–
Schlagworte
Animals
,
axial diffusivity
,
Demyelinating Autoimmune Diseases, CNS - diagnosis
,
Demyelinating Autoimmune Diseases, CNS - pathology
,
Diffuse Axonal Injury - diagnosis
,
Diffuse Axonal Injury - pathology
,
Diffusion Magnetic Resonance Imaging - methods
,
diffusion tensor imaging
,
Disease Models, Animal
,
experimental autoimmune encephalomyelitis
,
Male
,
Mice
,
Mice, Inbred C57BL
,
Multiple Sclerosis - diagnosis
,
Multiple Sclerosis - pathology
,
Nerve Fibers, Myelinated - pathology
,
radial diffusivity
,
ROC Curve
,
spinal cord injury
,
Statistics, Nonparametric
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